Results
| PMID | 12934347 |
| Gene Name | BAX |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 45 |
| Population details | 45 (16 patients with adenomyosis, 12 ovarian endometriosis, and 17 normal endometrum) |
| Sex | Female |
| Associated genes | Bcl-2, Bax |
| Other associated phenotypes |
Endometriosis, Adenomyosis |
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Hunan Yi Ke Da Xue Xue Bao. 2003 Apr;28(2):102-6. Huang, Feng-ying| Lin, Qiu-hua| Fang, Xiao-ling Department of Obstetrics and Gynecology, Second Xingya Hospital, Central South University, Changsha 410011, China. OBJECTIVE: To study the pathophysiological effect of the expression of the apoptosis-regulating protein Bcl-2 and Bax in endometrosis. METHOD: Samples were obtained from 16 patients with adenomyosis, 12 ovarian endometriosis, and 17 normal endometrum. Bcl-2 and Bax expression were examined by immunohistochemical ABC staining with specific monoclonal antibodies. RESULTS: 1. The expression of Bcl-2 or Bax in the eutopic endometrium was the same as the normal endometrium and their immunoreactivity was found predominately in the glandular epithelial cells, showing obvious cyclic changes. 2. The Bcl-2 and Bax expression in adenomyosis was not the cyclic change in ectopic glandular cells. 3. Less expression of Bcl-2 and Bax was found in the ovarian endometriosis. CONCLUSIONS: 1. The Bcl-2 and Bax cyclic change may play an important role in the proliferation and physiologic death of normal and eutopic endometrial glandular epithelial cells. 2. Bcl-2 may play an important role in forming adenomyosis. 3. Bcl-2 may be the cause of forming chocolate cyst by prompting apoptosis. Mesh Terms: Adult| Apoptosis| Endometriosis/genetics/*metabolism| Endometrium/metabolism| Female| Humans| Middle Aged| Ovarian Diseases/genetics/*metabolism| Proto-Oncogene Proteins/*biosynthesis/genetics| Proto-Oncogene Proteins c-bcl-2/*biosynthesis/geneti |
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